ABSTRACT
Polyglandular autoimmunity (PGA) type 2 presenting in childhood is extremely rare. We report a case of type 2 PGA who had hypothyroidism, followed by diabetic ketoacidosis and was later diagnosed to have adrenal insufficiency also.
Subject(s)
Adolescent , Diabetes Mellitus, Type 2/complications , Humans , Polyendocrinopathies, Autoimmune/complicationsABSTRACT
The etiology of slipped capital femoral epiphysis (SCFE) is unknown, though hormonal as well as mechanical factors have been implicated. We report a case of gigantism who presented with SCFE. This case provides an insight into the genesis of SCFE, which in this case was related to growth hormone excess and sex-hormone deficiency.
Subject(s)
Adult , Body Constitution , Epiphyses, Slipped/etiology , Femur Head/diagnostic imaging , Gigantism/complications , Gonadal Steroid Hormones/deficiency , Growth Disorders/complications , Growth Hormone/adverse effects , Humans , Internal Fixators , MaleABSTRACT
Hyperthyroidism is seen in 3.5-26% of acromegalic subjects, and can occur through TSH-dependent or independent mechanisms. Thyrotoxicosis as the first presenting illness in acromegaly is particularly uncommon, as described in this patient who had both acromegaly and a toxic thyroid adenoma.